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The main enzymes involved in NADPH production, ME1, IDH1, G6PD, and PGD, are all regulated in part by Nrf2 [61, 115, 121, 375, 376], with low levels of the cofactor seen in Nrf2 โ/โ mice and correspondingly high levels in mice with hepatocyte-specific Keap1 knockout [115]
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Its role in maturation and function of cells of the immune system and protection against shock in mice
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