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SIRT1 also governs gluconeogenesis by deacetylating transcriptional regulators such as CREB-regulated transcription coactivator 2 (CRTC2), forkhead box O1 (FOXO1), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) [24]
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Patients should tell the clinician about current pregnancy, breastfeeding, fertility treatment, and near-term pregnancy plans before therapy is selected
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