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When animals were treated with the mitochondria-targeted MnSOD mimetic Mito-TEMPO, the prevention of peroxynitrite formation due to superoxide dismutation eliminated necrotic cell death 6 h after APAP administration with no evidence of apoptosis [29, 58]
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Moreover, megadoses of up to 2,000 mcg are considered safe in treating B12 deficiency, but it’s best to avoid excessive amounts of any vitamin, especially when not needed
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