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Wnt is down-regulated during the dormancy stage by autocrine DKK1 to avoid immune surveillance, [81] as well as during the dissemination stages by intracellular Dact1

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As in the combination regimens of chemotherapeutics plus Tα1 adopted for treatment of many cancer types (Garaci et al., 2015), in MS a combination of disease modifying therapies with synthetic Tα1 may help in addressing and correctly modulating the repopulation of B cell compartment towards a more regulatory and anti-inflammatory phenotype